加酸提高全有机碱性水稳剂循环水浓缩倍数的运行

通过对循环水全有机碱性水质稳定剂实际应用情况的研究,结合饱和指数（Is）、稳定指数（RIS）、结垢指数（PSI）等指数的计算,在保证循环水水质稳定的前提下,通过适度加酸改变原设计的自然pH值运行方式,将循环水浓缩倍数由3倍提升至5倍运行,达到降低循环水药剂消耗和补水耗量的同时减少排污水量,实现节能减排的目的。     

聚丙烯装置循环气管道设计与应力分析

聚丙烯(PP)在市场上的应用非常普遍,丙烯聚合反应则是合成聚丙烯的重要手段。循环气压缩则是丙烯聚合反应的心脏,维持流化床反应的进行。本文从聚合反应的基本工艺、设备及管道布置、应力分析等方面对循环气管道的设计提出建设性意见。     

70m~3和108m~3聚合釜生产PVC对比

介绍了河南神马氯碱发展有限责任公司70 m3和108 m3聚合釜PVC生产装置的工艺特点和控制要求,从生产工艺、控制水平、生产效率、安全性能及DCS系统等方面对两套生产装置进行了比较和总结。     

Mangiferin Facilitates Islet Regeneration and β-Cell Proliferation through Upregulation of Cell Cycle and β-Cell Regeneration Regulators

Mangiferin, a xanthonoid found in plants including mangoes and iris unguicularis, was suggested in previous studies to have anti-hyperglycemic function, though the underlying mechanisms are largely unknown. This study was designed to determine the therapeutic effect of mangiferin by the regeneration of β-cells in mice following 70% partial pancreatectomy (PPx), and to explore the mechanisms of mangiferin-induced β-cell proliferation. For this purpose, adult C57BL/6J mice after 7–14 days post-PPx, or a sham operation were subjected to mangiferin (30 and 90 mg/kg body weight) or control solvent injection. Mangiferin-treated mice exhibited an improved glycemia and glucose tolerance, increased serum insulin levels, enhanced β-cell hyperplasia, elevated β-cell proliferation and reduced β-cell apoptosis. Further dissection at the molecular level showed several key regulators of cell cycle, such as cyclin D1, D2 and cyclin-dependent kinase 4 (Cdk4) were significantly up-regulated in mangiferin-treated mice. In addition, critical genes related to β-cell regeneration, such as pancreatic and duodenal homeobox 1 (PDX-1), neurogenin 3 (Ngn3), glucose transporter 2 (GLUT-2), Forkhead box protein O1 (Foxo-1), and glucokinase (GCK), were found to be promoted by mangiferin at both the mRNA and protein expression level. Thus, mangiferin administration markedly facilitates β-cell proliferation and islet regeneration, likely by regulating essential genes in the cell cycle and the process of islet regeneration. These effects therefore suggest that mangiferin bears a therapeutic potential in preventing and/or treating the diabetes.     

Damage of Neuroblastoma Cell SH-SY5Y Mediated by MPP+ Inhibits Proliferation of T-Cell Leukemia Jurkat by Co-Culture System

The adaptive immune system has implications in pathology of Parkinson’s disease (PD). Research data demonstrated that the peripheral CD4⁺ T-cell population decreased in pathogenesis of PD. The effect of damaged dopaminergic neurons on peripheral T cells of PD is still unknown. In this study, we constructed a neuronal and glial cells co-culture model by using human neuroblastoma cells SH-SY5Y and gliomas cells U87. After the co-culture cells were treated with neurotoxin 1-methyl-4-phenylpyridinium (MPP⁺) for 24 h, the conditioned media was harvested and used to cultivate T-cell leukemia Jurkat cells for another 24 h. We then analyzed the cell proliferation, cell cycle and necrosis effect of Jurkat cells. The results showed that co-culture medium of SH-SY5Y and U87 cells with MPP⁺ treatment inhibited the proliferation of Jurkat cells compared to control medium without MPP⁺, even though the same concentration of MPP⁺ had very little toxicity to the Jurkat cell. Furthermore, co-culture medium with low concentration of MPP⁺ (100 µM) arrested Jurkat cells cycle in G2/M phase through increasing cell cycle division 2 (CDC2) and CyclinB1 expression level, whereas co-culture medium with high concentration of MPP⁺ (500 µM) induced Jurkat cell necrosis through cellular swelling and membrane breakage. Our data implies that damaged dopamine neurons with glial cells can lead to the reduced number or inhibited proliferation activity of peripheral T cells.     

不同降雨强度下红黏土边坡干湿循环试验研究

干湿循环过程中红黏土边坡力学参数发生了变化,红黏土边坡破坏特征和机理与一般土质边坡不同。以贵州红黏土为研究对象,采用浴霸–人工降雨模拟干湿循环,在室内制备了较大尺寸边坡模型,同时在边坡内部不同位置埋设含水率、孔隙水压力和温度传感器,分析了干湿循环下红黏土边坡力学参数演变规律和破坏机理。研究结果表明,随着深度增加,边坡土体含水率受降雨强度影响逐渐减弱,表层含水率受降雨强度影响明显。干燥期含水率呈现先增加后减小的现象。同一降雨强度下,坡脚含水率最大,其次为坡面、坡肩,最后为坡顶。表层孔隙水压力在降雨、渗透期上升,干燥期降低。降雨强度越大,温度变化幅度越大。随深度增加,边坡温度变化幅度逐渐减小。坡脚温度变化幅度较其他部位大。边坡破坏特征由溅蚀→面蚀→片蚀→裂缝→冲沟,未见明显的滑动面。     

雨洪调蓄视角下的城市人工湖水量平衡景观设计方法研究

作为水生态基础设施之一的城市人工湖,可以通过自身水量平衡的调节实现雨洪调蓄功能。但是当前城市人工湖规划建设普遍存在水量难以维持的矛盾。在厘清城市人工湖水量平衡基本原理与空间尺度的前提下,借助城市人工湖与自然湖泊水文循环过程的对比研究,构建出人工湖水量平衡过程,进而分析其8项水量平衡要素的影响因子及调控可行性,并从风景园林专业可控的视角,将城市人工湖水文循环过程与景观要素进行耦合,建立起以水量平衡为目标的城市人工湖景观设计导则,通过"空间结构对位"和"物质载体对应"2个设计步骤实现水量调控。以期为城市人工湖水量保持的现实问题提供普适性的规划设计方法体系,拓展水生态基础设施研究领域的范畴,为"海绵城市"的建设提供理论借鉴与实践参考。     

基于环境效能的屋顶绿化研究性设计——以同济大学屋顶花园为例

当前国际前沿的屋顶绿化研究表明,屋顶绿化的城市能源和城市生态环境等环境综合效能越来越受重视。结合屋顶绿化全生命周期分析,提出基于环境效能的“预研究、深化设计、效能评估”的屋顶绿化研究性设计,并将此设计方法应用于实际案例Joy Garden屋顶花园中,对其进行风环境和日照模拟,初步设计出3种方案,从安全性、环境效益和全生命周期的角度评价并确定最佳方案,在此基础上进行基于环境效能的深化设计项目建成后的效能评估结果表明,案例屋顶花园在建筑节能、雨洪管理、改善城市热环境、增加城市生物多样性等提高环境效能方面均起到一定的积极作用。     

冻融循环作用下尾矿坝的力学响应特征

寒区冻融环境条件下,尾矿砂的冻融、缩胀、损伤破坏给寒区尾矿坝工程造成极大的危害。为探究冻融循环作用下尾矿坝变形规律,揭示其变形机制。采用自主设计的尾矿坝相似模型试验装置,开展不同冻结温度(-5、-25、-45℃)条件下,尾矿坝的变形规律模型试验。借助土压力、激光位移、孔隙水压力传感器,采用动态数据采集仪采集相关数据,分析冻融循环过程中尾矿坝各关键位置应力、变形、孔隙水压力的动态变化规律。试验结果表明:坝体内应力随冻结温度的降低而增大,在冻融循环前期,尾矿坝各关键位置应力增长速度明显高于冻融循环其他阶段。坝体内孔隙水压力随冻结温度的降低而减小,坝体越深,孔隙水压力的变化幅度越大,周期性更强,也更具有规律性。冻结温度具有明显的位置效应,越靠近尾矿坝边缘,坝体变形量越大,变形速度越快。     

硫酸盐-干湿循环下高延性纤维增强水泥基材料的自愈合

采用1.0%,1.5%和2.0%预加拉伸应变,使养护7,28d龄期的高延性纤维增强水泥基复合材料(ECC)试件产生裂缝,研究其在经历10,20和30次硫酸盐-干湿循环后的裂缝特性、自愈合后的拉伸性能及自愈合产物.结果表明:带裂缝试件在经历不同循环次数后均表现出了良好的自愈合效果,残余裂缝的最大宽度和数量明显减少;养护7d试件经历10次循环后的残余裂缝最大宽度由愈合前的80μm降至25μm,养护28d试件经历30次循环后的残余裂缝最大宽度由愈合前的100μm降至50μm;67%以上带裂缝试件自愈合后的单轴拉伸应变能力接近甚至超过同样经历的对比用无裂缝空白试件;养护7d试件自愈合后的最终应力可分别恢复至75%以上,养护28d试件可恢复至131%以上;层状结构的CaCO_3晶体是ECC试件的主要自愈合产物.